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馬偕醫學院選課系統

馬偕醫學院學生學習歷程檔案
馬偕醫學院課程地圖平台
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北二區教學資源中心
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資料分析暨導引系統
工作職掌  

卓文隆 教授 (Cho, Wen-Long)

主要學歷:

  美國密西根州立大學 遺傳學博士  

現任:

2009/08 ~ Present 馬偕醫學院 教授兼/教務長
2017/08 ~ Present 國立陽明大學 醫學院臨床醫學研究所 兼任教授

連絡信箱:

2009 ~ Present wenlong_mmc@mmc.edu.tw

經歷:

2009 ~ 2017 國立陽明大學醫學院臨床醫學研究所 合聘教授
2008 ~ 2015 國立陽明大學 熱帶醫學學科 教授
2013 ~ 2014 馬偕醫學院 教授兼/教務長/全人教育中心主任
2010 ~ 2017 馬偕醫學院 教授兼/教務長/主任秘書
2011 ~ 2011 馬偕醫學院 教授兼/教務長/護理學系主任
2010 ~ 2010 馬偕醫學院 教授兼/教務長/資訊中心主任
2008 ~ 2009 馬偕醫學院 教授兼/教務長/全人教育中心主任
2001 ~ 2009 國立陽明大學熱帶醫學研究所暨學科 教授兼科主任/所長
2009 ~ Present Adaptive Science on Taiwan (台灣調適醫學會) 編輯委員
2002 ~ 2008 國科會生命科學研究推動中心 審議委員
2006 中美洲五邦交國國際合作交流 陽明大學代表人
2005 ~ 2008 巴布亞紐幾內亞國際醫療援助 計畫主持人
2005 ~ 2006 英國國家Medical Research Council (MRC) 計畫審查委員
2004 ~ Present 中國生理學雜誌 編輯委員
2005 ~ Present 免疫與感染雜誌 編輯委員
2004 ~ 2006 中國生理學雜誌 副主編
2003 ~ 2008 國立陽明大學熱帶醫學科 主任
2003 ~ 2007 國立陽明大學熱帶醫學研究所 所長
2003 ~ 2005 外交替代役專業訓練 熱帶疾病講座
2003 ~ 2004 國立陽明大學 研發處 副研發長
2002 ~ 2004 國科會寄生蟲,醫事技術,實驗診斷 學門召集人
2003 ~ 2004 外交替代役專業訓練 熱帶疾病講座
2002 ~ 2003 考試院公務人員高等考試暨普通考試 典試委員
1998 ~ 2007 國科會寄生蟲,醫事技術,實驗診斷學門 覆審委員
1997 ~ 2000 國立陽明大學 寄生蟲學科及研究所 主任與所長
1996 ~ 2005 台灣寄生蟲學雜誌 編輯委員
1994 ~ 2000 國立陽明大學 寄生蟲學科及研究所 副教授

教學專長:

  • 分子生物學
  • 細菌抗藥性
  • 熱帶醫學
  • 遺傳學

研究專長:

  1. 院內感染包曼尼不動桿菌(Ab菌)的診斷與抗藥性研究。
  2. 熱帶醫學分子生物學。
  3. 埃及斑蚊免疫系統的分生與生化的研究。
  4. 應用遺傳工程技術來預防蟲媒熱帶疾病的傅播。
  5. 登革熱病毐的相關研究。
  6. 巴布亞紐幾內亞(PNG)醫療外交及惡性瘧原蟲抗藥基因分子研究
  7. 所羅門群島醫療外交

專題研究:

  1. 利用蚊子基因轉殖系統來探討斑蚊抗菌蛋白DEFENSIN基因的調控 (國科會NSC 三年計畫,89/8/1-92/7/31)
  2. 埃及斑蚊分裂原活化蛋白激脢AaMEK3, AaMEK4和Aap38之磷酸化與生理功能的研究 (國科會NSC 三年計畫,91/8/1-94/7/31)
  3. 國科會寄生蟲學,醫事技術暨實驗診斷學門推動計畫 (國科會NSC91/1/1-92/12/31)
  4. 登革二型病毒受體的特性分析與純化 (國科會NSC 三年計畫,92/8/1-95/7/31)
  5. 衛生署疾管局新興寄生蟲感染症之分子檢驗技術開發
  6. 巴布亞紐幾內亞(PNG)醫療外交計畫
  7. 所羅門群島醫療外交計畫

國際期刊論著:

  1. Wu RCC and Cho WL* Cloning and characterization of microbial activated Aedes aegypti MEK4 (AaMEK4): influences of non-catalytic domains on enzymatic activity. Insect Molecular Biology 2014 Oct;23(5):644-55. (IP: 3.044; Ranking:3/87)
  2. Liao YT, Kuo SC, Lee7 YT, Chen CP, Lin SW, Shen LJ, Fung CP, Cho WL*, Chen TL. Sheltering effect and indirect pathogenesis of carbapenem-resistant Acinetobacter baumannii in polymicrobial infection. Antimicrob Agents Chemother. 2014 Jul;58(7):3983-90
  3. Chen HP, Jiang JK, Lai PY, Chen CY, Chou TY, Chen YC, Chan CH, Lin SF, Yang CY, Chen CY, Lin CH, Lin JK, Ho DM, Cho WL*, Chan YJ*. Tumoral presence of human cytomegalovirus is associated with shorter disease-free survival in elderly patients with colorectal cancer and higher levels of intratumoral interleukin-17. Clin Microbiol Infect. 2014 Jul;20(7):664-71. (IF= 5.197; R/C= 7/72)
  4. Lee YL, Liu CE, Cho WL, Kuo CL, Cheng WL, Huang CS, Liu CS. Presence of cytomegalovirus DNA in leucocytes is associated with increased oxidative stress and subclinical atherosclerosis in healthy adults. Biomarkers. 2014 Mar;19(2):109-13. doi: 10.3109/1354750X.2013.877967. Epub 2014 Jan 22.
  5. Tseng HK, Liu CP, Ho MW, Lu PL, Lo HJ, Lin YH, Cho WL*, Chen YC*. Microbiological, epidemiological, and clinical characteristics and outcomes of patients with cryptococcosis in Taiwan, 1997-2010. Taiwan Infectious Diseases Study Network (TIDSnet) for cryptococcosis. PLoS One. 2013 Apr 17;8(4):e61921.
  6. Tseng HK, Liu CP, Price MS, Jong AY, Chang JC, Toffaletti DL, Betancourt-Quiroz M, Frazzitta AE, Cho WL*, Perfect JR*.  Identification of genes from the fungal pathogen Cryptococcus neoformans related to transmigration into the central nervous system. PLoS One. 2012, 7(9):e45083.
  7. Lee YT, Fung CP, Wang FD, Chen CP, Chen TL, Cho WL. Outbreak of imipenem-resistant Acinetobacter calcoaceticus-Acinetobacter baumannii complex harboring different carbapenemase gene-associated genetic structures in an intensive care unit, J Microbiol Immunol Infect. 2012, 45, 43-51.
  8. Jong A, Wu CH, Gonzales-Gomez I, Kwon-Chung KJ, Chang YC, Tseng HK, Cho WL, Huang SH.  Hyaluronic acid receptor CD44 deficiency is associated with decreased Cryptococcus neoformans brain infection. J Biol Chem. 2012, 287, 15298-306. (IF: 4.773)
  9. Chen HP, Jiang JK, Chen CY, Chou TY, Chen YC, Chang YT, Lin SF, Chan CH, Yang CY, Lin CH, Lin JK, Cho WL*, Chan YJ*. Human cytomegalovirus preferentially infects the neoplastic epithelium of colorectal cancer: A quantitative and histological analysis. J Clin Virol. 2012, 54, 240-4
  10. Lee YT, Chen TL, Lin YC, Fung CP, Cho WL. Nosocomial nasal myiasis in an intubated patient. J Chin Med Assoc., 2011, 74(8):369-71.
  11. Te-Li Chen, Yi-Tzu Lee, Roy Chen-Chih Wu, Cho WL*. Adaptation of Acinetobacter baumannii to carbapenem pressure, Adaptive Medicine, 2010, 2(2), 95-103
  12. Chen TL, Chang WC, Kuo SC, Lee YT, Chen CP, Siu LK, Cho WL, Fung CP. Contribution of a plasmid-borne blaOXA-58 gene with its hybrid promoter provided by IS1006 and an ISAba3-like element to beta-lactam resistance in acinetobacter genomic species 13TU. Antimicrob Agents Chemother. 2010, 54(8):3107-12.
  13. Lee YT, Turton JF, Chen TL, Wu RC, Chang WC, Fung CP, Chen CP, Cho WL, Huang LY, Siu LK.  (2009) First identification of blaOXA-51-like in non-baumannii Acinetobacter spp. J Chemother. 2009 Nov;21(5):514-20
  14. Hung YT, Lee YT, Huang LJ, Chen TL, Yu KW, Fung CP, Cho WL, Liu CY. (2009) Clinical characteristics of patients with Acinetobacter junii infection. J Microbiol Immunol Infect. 42(1):47-53.
  15. Lee YT, Huang LY, Chiang DH, Chen CP, Chen TL, Wang FD, Fung CP, Siu LK, Cho WL. (2009) Differences in phenotypic and genotypic characteristics among imipenem-non-susceptible Acinetobacter isolates belonging to different genomic species in Taiwan. Int J Antimicrob Agents. 34(6):580-4.
  16. Lee YT, Huang LY, Chen TL, Siu LK, Fung CP, Cho WL, Yu KW, Liu CY. (2009) Gene cassette arrays, antibiotic susceptibilities, and clinical characteristics of Acinetobacter baumannii bacteremic strains harboring class 1 integrons. J Microbiol Immunol Infect. 42(3):210-9.
  17. Lee YT, Turton JF, Chen TL, Wu RC, Chang WC, Fung CP, Chen CP, Cho WL, Huang LY, Siu LK. (2009) First identification of blaOXA-51-like in non-baumannii Acinetobacter spp. J Chemother. 21(5):514-20
  18. Te-Li Chen, Leung-Kei Siu, Yi-Tzu Lee, Chien-Pei Chen, Li-Yueh Huang, Roy Chen-Chih Wu, Cho WL, and Chang-Phone Fung. (2008) Acinetobacter baylyi as a Pathogen for Opportunistic Infection. Journal of Clinical Microbilogy, 46, 2938-2944.
  19. >Chien-Wei Liao, Chia-Kwung Fan§, Ting-Chang Kao, Dar-Der Ji , Kua-Eyre Su , Yun-Ho Lin , Cho WL§ (2008) Brain injury-associated biomarkers of TGF-β1, S100B, GFAP, NF-L, tTG, AβPP, and tau were concomitantly enhanced and the UPS was impaired during acute brain injury caused by Toxocara canis in mice. BMC Infectious Diseases, 24, 84-.99.
  20. Chien-Wei Liao, Cho WL,* Ting-Chang Kao, Kua-Eyre Su, Yun-Ho Lin, Chia-Kwung Fan* (2008) Blood-brain barrier impairment with enhanced SP, NK-1R, GFAP, and Claudin-5 expressions in experimental cerebral toxocariasis. Parasite Immunology, 30, 525-534. * indicates corresponding author.
  21. Chen HP, Lin JC, Yang SP, Lan YC, Weng WS, Tsai CH, Ho DM, Liu CY, Cho WL, Chan YJ. (2008) The type-2 variant of human cytomegalovirus glycoprotein N (gN-2) is not the rarest in the Chinese population of Taiwan: Influence of primer design. J Virol Methods, 151, 161-164.
  22. Li-Yueh Huang; Te-Li Chen; Po-Liang Lu; Che-An Tsai; Cho WL; Fang-Yee Chang; Chang-Phone Fung; Leung Kei Siu (2008) Dissemination of Multidrug-Resistant Acinetobacter baumannii Carrying Class 1 Integrons in Taiwan. Clinical Microbiology and Infection.14, 1010-1019.
  23. Te-Li Chen, Roy Chen-Chih Wu, Men-Fang Shaio, Chang-Phone Fung, and Cho WL (2008) Acquisition of a Plasmid Borne blaOXA-58 Gene with an Upstream IS1008 Insertion Conferring a High Level of Carbapenem Resistance to Acinetobacter baumannii. Antimicrobial Agents and Chemotherapy, 52, 2573-2580.
  24. Han-Yueh Kuo, Dung-Hung Chiang, Chien-Chun Wang, Te-Li Chen, Chang-Phone Fung, Chih-Pei Lin, Cho WL, Cheng-Yi Liu (2008) Clinical significance of Blastocystis hominis: an experience from a medical center in northern Taiwan. Journal of Microbiology, Immunology and Infection, 41, 222-226.
  25. George F. Mayhew, Lyric C. Bartholomay, Hang-Yen Kou, Thomas A. Rocheleau, Jeremy F. Fuchs, Matthew T. Aliota, I-Yu Tsao, Chiung-Yen Huang, Tze-Tze Liu, Kwang-Jen Hsiao, Shih-Feng Tsai,Ueng-Cheng Yang,  Nicole T. Perna, Cho WL, Bruce M. Christensen and Cheng-Chen Chen. (2007) Construction and characterization of an expressed sequenced tag library for the mosquito vector Armigeres subalbatus. BMC Genomics, 8, 462-
  26. Chen, T. L., Siu, L. K., Wu, R. C. C., Shaio, M. F., Huang, L. Y., Fung, C. P., Lee, C. M. and Cho WL (2007) Comparison of one-tube multiplex PCR and automated ribotyping for rapid identification of Acinetobacter baumannii. Clinical Microbiology and Infection, 13, 801-806
  27. Wu, R.C.C., Shaio, M.F., and Cho WL (2007) A p38 MAP kinase regulates the expression of the Aedes aegypti defensin gene in mosquito cells. Insect Molecular Biology, (16, 389-399)
  28. Chen, T. L., Chuang, C. L., Siu, L. K., Fung, C. P., and Cho WL (2007) Genomic species identification is important to delineate the pathological characteristics of Acinetobacter in tunneled, cuffed hemodialysis catheter-related bacteremia. Nephrology Dialysis Transplantation, 22, 936-938.
  29. Liu, I.H, Chung, Y.M, Chen, S.J, Cho WL (2006) Necrotizing Retinitis Induced by Angiostrongylus cantonensis. American journal of ophthalmology, 141: 577-579
  30. *Bartholomay, L. C., *Cho WL, Rocheleau, T. A. Boyle, J. P., Beck, E. T., Fuchs, J. F., Liss, P., Rusch, M., Butler, K. M., Wu, R. C. C., Lin, S. P., Kou, H. Y., Tsao, I. Y., Huang, C. Y., Wu, T. T, . Hsiao, K. J., Tsai, S. F., Yang, U. C., Nappi, A. J., Perna, N. T., Chen, C. C., and Christensen, B. M. (2004) Toward a description and transcriptomes of immune-activated hemocytes from the mosquito vectors, Aedes aegypti and Armigeres subalbatus. Infection and Immunity, 72: 4114-4126. * indicates the equal contributions.
  31. Huang, S. J., Li, S. Y., Wu, R. C. C., Shaio, M. F., Wang, P. S. and Cho WL (2003) An immune signaling kinase AaMEK3 from mosquitoes: cDNA cloning and characterization. Insect Molec. Biol.12, 595-603.
  32. Chiao, Y. C., Cho WL and Wang, P.S. (2002) Inhibition of testosterone production by propylthiouracil in rat leydig cells. Biology of Reproduction, 67, 416-422.
  33. Cho WL and Raikhel, A.S. (2001) A novel function of 20-hydroxyecdysone: translational repression of the lysosomal protease mRNA in the mosquito fat body. Insect Biochem. Molec. Biol. 31, 283-288.
  34. *Vladimir Kokoza, *Abduelaziz Ahmed, *Cho WL, Nijole Jasinskiene , Anthony A. James  and Alexander Raikhel  (2000) Engineering blood meal-activated systemic immunity in the mosquito vector. Proc. Natl. Acad. Sci. (USA) 97, 9144-9149. (NSC 90-2320-B-010-093) (*Cho WL, Kokoza, K. and Ahmed, A. have equal contribution indicated in the paper)
  35. Lo, Ming-Jae, Kau, Mei-Mei, Cho WL, Wang, P. S. (2000) Aging effects on the secretion of corticosterone in male rats.  J. Investigative Medicine. 48, 335-342.
  36. Kau, M. -M., Chen, J. -J., Wang, S. -W., Cho WL, Wang, P. S. (1999) Age-related impairment of aldosterone secretion in zona glomerulosa cells of ovariectomized rats. J. Investigative Medicine, 47, 425-432.
  37. Cho WL, Tsao, S. -M., Hays, A. R., Walter, R., Chen, J. -S., Snigirevskaya, E. S., and Raikhel, A. S. (1999) Mosquito cathepsin B-like protease involved in embryonic degradation of vitellin as a latent extraovarian precursor, J. Biol. Chem.   274, 13311-13321.
  38. Kapittskaya, M. Z., Dittmer, N. T., Deitsch, K. W., Cho WL, Taylor, D. G., Leff, T., Raikhel, A. S., (1998) Three isoforms of an HNF-4 transcription factor with tissue- and stage-specific expression in the adult mosquito, J. Biol. Chem. 273, 29801-29810.
  39. Huang, A. –M., Chang, T. –J., Cho WL, Chou, C. –K. (1998) From mosquito to man: Identification of a novel protein kinase, HsHPK, which is highly expressed in human hepatoma tissues. J. Biomedical Science, 5, 135-140
  40. Chiou, J. –Y., Huang, S. –J., Huang, S. –T., Cho WL (1998) Identification of immune-related protein kinases from mosquitoes (Aedes aegypti), J. Biomedical Science, 5, 120-126
  41. Cho WL, Liu, S. H., Lee, C. H., Kuo, C. C., Chang, C. I., and Chen, C. C., (1998) Molecular cloning, characterization and tissue expression of phenoloxidase cDNA from mosquito Armigeres subalbatus inoculated with Dirofilaria immitis Microfilariae, Insect Molecular Biology, 7, 1-10.
  42. Cho WL, Fu, T. -F., Chiou, J. -Y., and Chen, C. -C. (1997) Molecular characterization of a defensin gene from mosquito, Aedes aegypti. Insect Biochem. Molec. Biol. 27, 351-358.
  43. Cho WL, Fu, Y. -C, Chen, C. -C., and Ho, C. -M. (1996) Cloning and characterization of cDNAs encoding the antibacterial peptide, defensin A, from mosquito , Aedes aegypti. Insect Biochem. Molec. Biol. 26, 395-402.
  44. Sappington, T. W., Kokoza, V. A., Cho WL, and Raikhel, A. S. (1996) Molecular characterization of the mosquito vitellogenin receptor reveals unexpected high homology to the Drosophila yolk protein receptor. Proc. Natl. Acad. Sci. (USA) 93, 8934-8939.
  45. Cho WL, Kapitskaya, M. Z. and Raikhel, A. S. (1995) Mosquito ecdysteroid receptor: Analysis of the cDNA and expression during vitellogenesis. Insect Biochem. Molec. Biol., 25, 19-27
  46. Deitsch, K. W., Dittmer, N., Kapitskaya, Chen, J. -S., Cho WL, and Raikhel, A. S. (1995) Regulation of gene expression by 20-hydroxyecdysone in the fat body of Aedes aegypti (Diptera: Culicidae) Eur. J. Entomol. 92, 237-244.
  47. Chen, J. -S., Cho WL, Raikhel, A. S. (1994) Analysis of mosquito vitellogenin cDNA. J. Mol. Biol. 237, 641-647.
  48. Cho WL, Deitsch, K. W., Chen, J. S., Ditmer, N. T. and Raikhel, A. S. (1993) Molecular Studies of Mosquito Vitellogenesis, in: Host Regulated Developmental Mechanisms In Vector Arthropods (Eds. Borovsky, D. and Spielman, A.) 48-55.
  49. Cho WL, Raikhel, A. S. (1992) Cloning of cDNA for mosquito lysosomal aspartic protease. J. Biol. Chem. 267, 21823-21829.
  50. Cho WL, Deitsch, K. W. and Raikhel, A. S., (1991) An extraovarian protein accumulated in mosquito oocytes is a carboxypeptidase activated in embryos. Proc. Natl. Acad. Sci. (U. S. A.), 88, 10821-10824.
  51. Cho WL, Dhadialla, T. S. and Raikhel, A. S. (1991) Purification and characterization of a lysosomal aspartic protease with cathepsin D activity from the mosquito. Insect Biochem., 21, 165-176.
  52. Raikhel, A. S., Dhadialla, T. S., Cho WL, Hays, A. R. and Koller, C. N. (1990) Biosynthesis and endocytosis of yolk proteins in the mosquito. In : Molecular Insect Science (Eds. Hagedorn, H. H., Hildebrand, J. G., Kidwell, M. G., and Law, J. H.), Plenum, New York, 147-154.